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However, despite the progress that has been made with the 3D cocultures, preclinical (animal) models, especially the application of mice remain the common experimental system that is currently used to study the pathogenesis of DILI [5254]

It does not constitute guidance on human or animal use and should not be interpreted as such

Different CRN architectures, including pH-responsive polymeric micelles, lipid-based nanoparticles, and dendrimer-based systems, have demonstrated improved tumour penetration and minimised systemic toxicity in murine and xenograft models

Discussion The ReCePI study aims to demonstrate the safety and efficacy of amustaline/GSH pathogen-reduced RBCs in subjects treated for acute anemia related to bleeding where transfusions are indicated to prevent tissue hypoxia